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FBXO3 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UK99
Clone Names 91009083
Peptide ID 91009083
Additional Information
Gene ID 26273
Other Names F-box only protein 3, FBXO3, FBX3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9195b was selected from the C-term region of human FBXO3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXO3
Synonyms FBX3
Function Substrate recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53- dependent transactivation.
Cellular Location Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies
Research Areas
Citations (0)

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FBXO3 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs.


Shima,Y.,, Mol. Cell. Biol. 28 (23), 7126-7138 (2008)Ilyin,G.P.,, Genomics 67 (1), 40-47 (2000)

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$ 80.00
Cat# BP9195b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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