|Other Names||rRNA-processing protein FCF1 homolog, FCF1, C14orf111|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9196b was selected from the C-term region of human FCF1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.|
|Cellular Location||Nucleus, nucleolus.|
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Provided below are standard protocols that you may find useful for product applications.
FCF1 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs.
Shima,Y., et.al., Mol. Cell. Biol. 28 (23), 7126-7138 (2008)Ilyin,G.P., et.al., Genomics 67 (1), 40-47 (2000)
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