|Other Names||Nucleolar protein 58, Nucleolar protein 5, NOP58, NOL5, NOP5|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9202b was selected from the C-term region of human NOP5/NOP58. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs.|
|Cellular Location||Nucleus, nucleolus. Nucleus, nucleoplasm|
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Provided below are standard protocols that you may find useful for product applications.
Nop5p (a.k.a. Nop58p), is localized in the nucleolus and required for pre-18S rRNA processing in S. cerevisiae (baker's yeast).
McKeegan,K.S., et.al., Mol. Cell. Biol. 29 (18), 4971-4981 (2009)McKeegan,K.S., et.al, Mol. Cell. Biol. 27 (19), 6782-6793 (2007)
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