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ACCN1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q16515
Clone Names 90805001
Peptide ID 90805001
Additional Information
Gene ID 40
Other Names Acid-sensing ion channel 2, ASIC2, Amiloride-sensitive brain sodium channel, Amiloride-sensitive cation channel 1, neuronal, Amiloride-sensitive cation channel neuronal 1, Brain sodium channel 1, BNC1, BNaC1, Mammalian degenerin homolog, ASIC2, ACCN, ACCN1, BNAC1, MDEG
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9213c was selected from the Center region of human ACCN1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ASIC2
Function Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
Cellular Location Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes.
Tissue Location Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary
Research Areas
Citations (0)

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ACCN1 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this protein may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium.


Bashari,E.,, Am. J. Physiol., Cell Physiol. 296 (2), C372-C384 (2009)Chai,S.,, J. Biol. Chem. 282 (31), 22668-22677 (2007)

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$ 80.00
Cat# BP9213c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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