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UPK1A Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O00322
Clone Names 90909161
Peptide ID 90909161
Additional Information
Gene ID 11045
Other Names Uroplakin-1a, UP1a, Tetraspanin-21, Tspan-21, Uroplakin Ia, UPIa, UPKa, UPK1A, TSPAN21
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9225b was selected from the C-term region of human UPK1A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UPK1A
Synonyms TSPAN21
Function Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location High expression restricted to ureteric urothelium (most superficial cells); low expression in prostate Expression in normal urothelial cells is lost in culture. Some expression in tumor cell lines derived from urothelial malignancies.
Research Areas
Citations (0)

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The protein is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.


Wang,H.,, J. Mol. Biol. 392 (2), 352-361 (2009)Hall,G.D.,, Biochim. Biophys. Acta 1729 (2), 126-134 (2005)

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$ 80.00
Cat# BP9225b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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