|Other Names||Claudin-18, CLDN18|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9229b was selected from the C-term region of human CLDN18. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity.|
|Cellular Location||Cell junction, tight junction. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Concentrated at the cell-cell borders of epithelial cells|
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Provided below are standard protocols that you may find useful for product applications.
CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells.
Sahin,U., et.al., Clin. Cancer Res. 14 (23), 7624-7634 (2008)Zwiers,A., et.al, Inflamm. Bowel Dis. 14 (12), 1652-1659 (2008)
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