|Other Names||Ectonucleoside triphosphate diphosphohydrolase 1, NTPDase 1, Ecto-ATP diphosphohydrolase 1, Ecto-ATPDase 1, Ecto-ATPase 1, Ecto-apyrase, Lymphoid cell activation antigen, CD39, ENTPD1, CD39|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9233a was selected from the N-term region of human ENTPD1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Expressed primarily on activated lymphoid cells. Also expressed in endothelial tissues. Isoform 1 and isoform 3 are present in both placenta and umbilical vein, whereas isoform 2 is present in placenta only|
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Provided below are standard protocols that you may find useful for product applications.
In the nervous system, ENTPD1 could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. ENTPD1 Could also be implicated in the prevention of platelet aggregation, Hydrolyzes ATP and ADP equally well.
Spanevello,R.M., et.al., Clin. Chim. Acta 411 (3-4), 210-214 (2010)Ndhlovu,L.C., et.al, Eur. J. Immunol. 40 (1), 134-141 (2010)
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