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SLC22A6 Antibody (C-Term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q4U2R8
Other Accession NP_004781
Clone Names 91023060
Peptide ID 91023060
Additional Information
Gene ID 9356
Other Names Solute carrier family 22 member 6, Organic anion transporter 1, hOAT1, PAH transporter, hPAHT, Renal organic anion transporter 1, hROAT1, SLC22A6, OAT1, PAHT
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9237b was selected from the C-Term region of human SLC22A6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC22A6
Synonyms OAT1, PAHT
Function Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p- aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido- 3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro- phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2- furanpropionate (CMPF), cidofovir, adefovir, 9-(2- phosphonylmethoxyethyl) guanine (PMEG), 9-(2- phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p- chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule
Research Areas
Citations (0)

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The protein is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane.


Hong,M.,, J. Pharmacol. Exp. Ther. 332 (2), 650-658 (2010)Shin,H.J.,, Clin. Chim. Acta 411 (1-2), 99-105 (2010)

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$ 80.00
Cat# BP9237b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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