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MEF2A Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q02078
Clone Names 90625122
Peptide ID 90625122
Additional Information
Gene ID 4205
Other Names Myocyte-specific enhancer factor 2A, Serum response factor-like protein 1, MEF2A, MEF2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9258c was selected from the Center region of human MEF2A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MEF2A
Synonyms MEF2
Function Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00251, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:16563226}
Tissue Location Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. Isoform RSRFC4 and isoform RSRFC9 are expressed in all tissues examined
Research Areas
Citations (0)

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MEF2A is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this protein could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1).


Wu,Y.,, J. Mol. Biol. 397 (2), 520-533 (2010)Ishikawa,F.,, Oncogene 29 (6), 909-919 (2010)

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$ 80.00
Cat# BP9258c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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