|Other Names||Thromboxane A2 receptor, TXA2-R, Prostanoid TP receptor, TBXA2R|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9264c was selected from the Center region of human TBXA2R. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
TBXA2R encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis.
Mumford,A.D., et.al, Blood 115 (2), 363-369 (2010)Saito,M., et.al, Cell. Signal. 22 (1), 41-46 (2010)Gannon,A.M., et.al, J. Mol. Biol. 394 (1), 29-45 (2009)
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