TBXA2R Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P21731 |
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Clone Names | 90805114 |
Gene ID | 6915 |
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Other Names | Thromboxane A2 receptor, TXA2-R, Prostanoid TP receptor, TBXA2R |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP9264c was selected from the Center region of human TBXA2R. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TBXA2R |
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Function | Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. |
Cellular Location | Cell membrane; Multi-pass membrane protein. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TBXA2R encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis.
References
Mumford,A.D., et.al, Blood 115 (2), 363-369 (2010)Saito,M., et.al, Cell. Signal. 22 (1), 41-46 (2010)Gannon,A.M., et.al, J. Mol. Biol. 394 (1), 29-45 (2009)
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