|Other Names||Actin-related protein 5, hARP5, Sarcoma antigen NY-SAR-16, ACTR5, ARP5|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9266b was selected from the C-term region of human ACTR5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.|
|Cellular Location||Nucleus Cytoplasm. Note=Predominantly nuclear but undergoes nucleo-cytoplasmic shuttling (PubMed:19014934). Localized to interphase nuclei, but not nucleoli; excluded from chromosomes as mitosis progresses (PubMed:18163988)|
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Provided below are standard protocols that you may find useful for product applications.
ACTR5 may be involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex
Kitayama,K., et.al, Exp. Cell Res. 315 (2), 206-217 (2009)Jin,J., et.al, J. Biol. Chem. 280 (50), 41207-41212 (2005)Lee,S.Y., et.al, Proc. Natl. Acad. Sci. U.S.A. 100 (5), 2651-2656 (2003)
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