|Other Names||Cyclin-dependent kinase 2-interacting protein, CDK2-interacting protein, CINP|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9272c was selected from the Center region of human CINP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.|
|Cellular Location||Nucleus. Note=Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication|
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Provided below are standard protocols that you may find useful for product applications.
CINP interacts with CDK2, MCM5, and CDC7, and is associated with the origin recognition complex protein ORC2. It acts as a homodimer and is involved in replication and ATR-mediated checkpoint signaling.
Lovejoy,C.A., et.al, Proc. Natl. Acad. Sci. U.S.A. 106 (46), 19304-19309 (2009)Grishina,I. et.al, Cell Cycle 4 (8), 1120-1126 (2005)
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