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PHF8 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UPP1
Clone Names 90826189
Peptide ID 90826189
Additional Information
Gene ID 23133
Other Names Histone lysine demethylase PHF8, PHD finger protein 8, PHF8, KIAA1111, ZNF422
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9276b was selected from the C-term region of human PHF8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PHF8
Synonyms KIAA1111, ZNF422
Function Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3.
Cellular Location Nucleus. Nucleus, nucleolus. Note=Recruited to H3K4me3 sites on chromatin during interphase. Dissociates from chromatin when cells enter mitosis
Research Areas
Citations (0)

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PHF8 is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. Defects in this protein are a cause of mental retardation syndromic X-linked Siderius type (MRXSSD).


Feng,W.,, Nat. Struct. Mol. Biol. 17 (4), 445-450 (2010)Yue,W.W.,, FEBS Lett. 584 (4), 825-830 (2010)Yu,L.,, Cell Res. 20 (2), 166-173 (2010)

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$ 80.00
Cat# BP9276b
(40 western blots)
Availability: In Stock
Bulk Size
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