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FBXO4 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UKT5
Clone Names 91009085
Additional Information
Gene ID 26272
Other Names F-box only protein 4, FBXO4, FBX4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9295c was selected from the Center region of human FBXO4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXO4
Synonyms FBX4
Function Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:18598945, PubMed:10531035, PubMed:29142209, PubMed:20181953). Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation (PubMed:18598945). Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (PubMed:16275645, PubMed:20159592). Promotes ubiquitination of FXR1 following phosphorylation of FXR1 by GSK3B, leading to FXR1 degradation by the proteasome (PubMed:29142209).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q8CHQ0}.
Research Areas
Citations (0)
citation

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Background

FBXO4 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein belongs to the Fbxs class.

References

Zeng,Z., et.al, Dev. Cell 18 (2), 214-225 (2010)Barbash,O., et.al, Cancer Cell 14 (1), 68-78 (2008)Sugiyama,N., et.al, Mol. Cell Proteomics 6 (6), 1103-1109 (2007)

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$ 277.78
Cat# BP9295c
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Availability: 2 weeks
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