FBXO4 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UKT5 |
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Clone Names | 91009085 |
Gene ID | 26272 |
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Other Names | F-box only protein 4, FBXO4, FBX4 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP9295c was selected from the Center region of human FBXO4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | FBXO4 |
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Synonyms | FBX4 |
Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:18598945, PubMed:10531035, PubMed:29142209, PubMed:20181953). Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation (PubMed:18598945). Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (PubMed:16275645, PubMed:20159592). Promotes ubiquitination of FXR1 following phosphorylation of FXR1 by GSK3B, leading to FXR1 degradation by the proteasome (PubMed:29142209). |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q8CHQ0}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
FBXO4 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein belongs to the Fbxs class.
References
Zeng,Z., et.al, Dev. Cell 18 (2), 214-225 (2010)Barbash,O., et.al, Cancer Cell 14 (1), 68-78 (2008)Sugiyama,N., et.al, Mol. Cell Proteomics 6 (6), 1103-1109 (2007)
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