|Other Names||Gamma-aminobutyric acid receptor subunit delta, GABA(A) receptor subunit delta, GABRD|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9299c was selected from the Center region of human GABRD. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
GABRD is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This protein encodes the delta subunit.
Gratacos,M., et.al, Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009)Maldonado-Aviles,J.G., et.al, Am J Psychiatry 166 (4), 450-459 (2009)Tabakoff,B., et.al, BMC Biol. 7, 70 (2009)
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