RNH2C Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8TDP1 |
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Clone Names | 91109178 |
Gene ID | 84153 |
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Other Names | Ribonuclease H2 subunit C, RNase H2 subunit C, Aicardi-Goutieres syndrome 3 protein, AGS3, RNase H1 small subunit, Ribonuclease HI subunit C, RNASEH2C, AYP1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP9303c was selected from the Center region of human RNH2C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RNASEH2C |
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Synonyms | AYP1 |
Function | Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. |
Cellular Location | Nucleus. |
Tissue Location | Widely expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
RNH2C encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes.
References
Chon,H., et.al., Nucleic Acids Res. 37 (1), 96-110 (2009)Rice,G., et.al., Am. J. Hum. Genet. 81 (4), 713-725 (2007)Crow,Y.J., et.al., Nat. Genet. 38 (8), 910-916 (2006)
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