|Other Names||TCF3 fusion partner, INO80 complex subunit F, Protein FB1, TFPT, INO80F|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9304a was selected from the N-term region of human TFPT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Appears to promote apoptosis in a p53/TP53-independent manner.|
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TFPT component of the chromatin-remodeling INO80 complex which, in addition to chromatin remodeling implicated in crucial functions such as DNA repair, checkpoint regulation, DNA replication, telomemere maintenance and chromosome segregation. This protein appears to promote apoptosis in a TP53/p53-independent manner.
Jiang,F., et.al., Cancer Lett. 253 (2), 265-272 (2007)Franchini,C., et.al., Apoptosis 11 (12), 2217-2224 (2006)Olsen,J.V., et.al., Cell 127 (3), 635-648 (2006)
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