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TYW2 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q53H54
Clone Names 91109207
Peptide ID 91109207
Additional Information
Gene ID 55039
Other Names tRNA wybutosine-synthesizing protein 2 homolog, tRNA-yW-synthesizing protein 2, tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase, TRMT12, TRM12, TYW2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9305b was selected from the C-term region of human TYW2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRMT12
Synonyms TRM12, TYW2
Function S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha- carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.
Research Areas
Citations (0)

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Background

TYW2 is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis.

References

Rodriguez,V., et.al., Genes Chromosomes Cancer 46 (7), 694-707 (2007)Noma,A. et.al., Nucleic Acids Symp Ser (Oxf) 50, 65-66 (2006)Kalhor,H.R., et.al., Biochem. Biophys. Res. Commun. 334 (2), 433-440 (2005)

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$ 80.00
Cat# BP9305b
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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