KLHL7 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8IXQ5 |
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Clone Names | 91109297 |
Gene ID | 55975 |
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Other Names | Kelch-like protein 7, KLHL7 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP9307c was selected from the Center region of human KLHL7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | KLHL7 |
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Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination. |
Cellular Location | Nucleus. Cytoplasm. Note=Colocalizes with CUL3 in punctate structures at the perinuclear region of the cytoplasm |
Tissue Location | Widely expressed, with highest levels in adult and fetal heart, CNS and adult testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
KLHL7 encodes a BTB-Kelch-related protein. The encoded protein may be involved in protein degradation.
References
Friedman,J.S., et.al., Am. J. Hum. Genet. 84 (6), 792-800 (2009)Bredholt,G., et.al, Scand. J. Immunol. 64 (3), 325-335 (2006)
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