|Other Names||Kelch-like protein 7, KLHL7|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9307c was selected from the Center region of human KLHL7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination.|
|Cellular Location||Nucleus. Cytoplasm. Note=Colocalizes with CUL3 in punctate structures at the perinuclear region of the cytoplasm.|
|Tissue Location||Widely expressed, with highest levels in adult and fetal heart, CNS and adult testis|
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Provided below are standard protocols that you may find useful for product applications.
KLHL7 encodes a BTB-Kelch-related protein. The encoded protein may be involved in protein degradation.
Friedman,J.S., et.al., Am. J. Hum. Genet. 84 (6), 792-800 (2009)Bredholt,G., et.al, Scand. J. Immunol. 64 (3), 325-335 (2006)
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