|Other Names||B-cell lymphoma 3 protein, BCL-3, Proto-oncogene BCL3, BCL3, BCL4, D19S37|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Ubiquitination via 'Lys- 63'-linked ubiquitin chains is required for nuclear accumulation|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
BCL3 is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers.
Kabuta,T. et.al., Biochem. Biophys. Res. Commun. 394 (3), 697-702 (2010)Talmud,P.J. et.al., Am. J. Hum. Genet. 85 (5), 628-642 (2009)Folco,E.J. et.al., J. Biol. Chem. 284 (38), 25569-25575 (2009)
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