GUSB Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P08236 |
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Gene ID | 2990 |
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Other Names | Beta-glucuronidase, Beta-G1, GUSB |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GUSB |
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Function | Plays an important role in the degradation of dermatan and keratan sulfates. |
Cellular Location | Lysosome. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The GUSB gene encodes beta-glucuronidase (EC 3.2.1.31), a lysosomal hydrolase involved in the stepwise degradation of glucuronic acid-containing glycosaminoglycans (Shipley et al., 1993 [PubMed 7680524]). It is a tetrameric glycoprotein composed of identical subunits (Oshima et al., 1987 [PubMed 3468507]). The GUSB gene is mutated in mucopolysaccharidosis type VII (MPS7; MIM 253220).
References
Tomatsu,S. Hum. Mutat. 30 (4), 511-519 (2009)Romanowski,T. Med. Sci. Monit. 14 (7), BR147-BR152 (2008)Gratz,M. Pharmacogenet. Genomics 15 (12), 875-881 (2005)
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