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PO4F3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q15319 |
|---|
| Gene ID | 5459 |
|---|---|
| Other Names | POU domain, class 4, transcription factor 3, Brain-specific homeobox/POU domain protein 3C, Brain-3C, Brn-3C, POU4F3, BRN3C |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | POU4F3 |
|---|---|
| Synonyms | BRN3C |
| Function | Acts as a transcriptional activator (PubMed:18228599). Acts by binding to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:18228599). Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (By similarity). |
| Cellular Location | Nucleus. Cytoplasm Note=Preferentially localized in the nucleus |
| Tissue Location | Brain. Seems to be specific to the retina. |
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Provided below are standard protocols that you may find useful for product applications.
Background
PO4F3 encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this protein are the cause of non-syndromic sensorineural deafness autosomal dominant type 15.
References
de Heer,A.M. Ann. Otol. Rhinol. Laryngol. 118 (4), 313-320 (2009)van Drunen,F.J. Audiol. Neurootol. 14 (5), 303-307 (2009)Collin,R.W. Hum. Mutat. 29 (4), 545-554 (2008)
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