|Other Names||POU domain, class 4, transcription factor 3, Brain-specific homeobox/POU domain protein 3C, Brain-3C, Brn-3C, POU4F3, BRN3C|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor. Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear.|
|Tissue Location||Brain. Seems to be specific to the retina.|
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Provided below are standard protocols that you may find useful for product applications.
PO4F3 encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this protein are the cause of non-syndromic sensorineural deafness autosomal dominant type 15.
de Heer,A.M. Ann. Otol. Rhinol. Laryngol. 118 (4), 313-320 (2009)van Drunen,F.J. Audiol. Neurootol. 14 (5), 303-307 (2009)Collin,R.W. Hum. Mutat. 29 (4), 545-554 (2008)
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