CP048 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H0I2 |
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Gene ID | 84080 |
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Other Names | Enkurin domain-containing protein 1, ENKD1, C16orf48 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ENKD1 |
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Synonyms | C16orf48 |
Function | Microtubule-binding protein which regulates microtubule organization and stability (PubMed:35197565, PubMed:35072334). Promotes the stability of astral microtubules and facilitates the proper orientation of the mitotic spindle (PubMed:35197565). This allows the oriented division of basal keratinocytes and contributes to epidermal stratification (By similarity). Required for the assembly of both primary and motile cilia (PubMed:35301795). Destabilizes the interaction between CCP110 and CEP97 by competing with CEP97 for binding to CCP110 which promotes the removal of CCP110 and CEP97 from the mother centriole and allows the initiation of ciliogenesis (PubMed:35301795). |
Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, cilium axoneme. Note=Localized at the centrosome and accumulates at the parental centrioles during centriole duplication in cycling cells (PubMed:35301795). In ciliated cells, detected at the basal body of the cilium (PubMed:35301795). Localizes to the centrosome during interphase, to the primary cilium at G0, to the spindle poles during mitosis and to the centrosomes and central spindle during telophase and cytokinesis (PubMed:35072334) |
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Provided below are standard protocols that you may find useful for product applications.
References
Xin,X. Genome Res. 19 (7), 1262-1269 (2009)Clark,H.F. Genome Res. 13 (10), 2265-2270 (2003)Simpson,J.C. EMBO Rep. 1 (3), 287-292 (2000)
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