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TCHP Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9BT92
Peptide ID 91109090
Additional Information
Gene ID 84260
Other Names Trichoplein keratin filament-binding protein, Protein TCHP, Mitochondrial protein with oncostatic activity, Mitostatin, Tumor suppressor protein, TCHP {ECO:0000312|EMBL:AAH042851}
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TCHP {ECO:0000312|EMBL:AAH04285.1}
Function Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed:15731013, PubMed:18931701). Is a negative regulator of ciliogenesis (PubMed:25270598).
Cellular Location Cytoplasm, cytoskeleton. Cytoplasm. Cell membrane Mitochondrion. Cell junction, desmosome
Tissue Location Expressed at high levels in normal urothelial and breast epithelial cells. Also expressed in the smooth muscle and endothelial cells. Reduced expression seen in advanced bladder and breast carcinomas (at protein level). Ubiquitous. Expressed at highest levels in the heart, skeletal muscle, kidney, liver and testis.
Research Areas
Citations (0)

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Background

TCHP may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. This protein may regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.

References

Vecchione,A. Oncogene 28 (2), 257-269 (2009)Tokumasu,F. J. Cell. Sci. 118 (PT 5), 1091-1098 (2005)Nishizawa,M. J. Cell. Sci. 118 (PT 5), 1081-1090 (2005)

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$ 80.00
Cat# BP9354c
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