|Other Names||1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase beta-4, Phosphoinositide phospholipase C-beta-4, Phospholipase C-beta-4, PLC-beta-4, PLCB4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction.|
|Tissue Location||Preferentially expressed in the retina.|
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Provided below are standard protocols that you may find useful for product applications.
PLCB4 catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina.
Okada, Y., et al. Hum. Mol. Genet. (2010) In press Sjoholm, L.K., et al. J Circadian Rhythms 8 (1), 1 (2010) Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009)
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