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MCM2 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P49736
Peptide ID 80522052
Additional Information
Gene ID 4171
Other Names DNA replication licensing factor MCM2, Minichromosome maintenance protein 2 homolog, Nuclear protein BM28, MCM2, BM28, CCNL1, CDCL1, KIAA0030
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MCM2
Synonyms BM28, CCNL1, CDCL1, KIAA0030
Function Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.
Cellular Location Nucleus.
Research Areas
Citations (0)

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MCM2 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.


Saade, E., et al. Proteomics 9(21):4934-4943(2009)Xu, X., et al. EMBO J. 28(19):3005-3014(2009)Liaw, K., et al. J. Cutan. Pathol. 36(10):1121-1122(2009)Im, J.S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(37):15628-15632(2009)Chuang, L.C., et al. Mol. Cell 35(2):206-216(2009)

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$ 80.00
Cat# BP9377c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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