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CROT Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UKG9
Peptide ID 80513061
Additional Information
Gene ID 54677
Other Names Peroxisomal carnitine O-octanoyltransferase, COT, CROT, COT
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CROT
Synonyms COT
Function Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl- CoA, to its corresponding carnitine ester.
Cellular Location Peroxisome.
Research Areas
Citations (0)

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Background

CROT encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.

References

Li, Y.L., et al. FEBS J. 276(1):303-314(2009)Morillas, M., et al. J. Biol. Chem. 277(13):11473-11480(2002)van der Leij, F.R., et al. Mol. Genet. Metab. 71 (1-2), 139-153 (2000) :Ferdinandusse, S., et al. Biochem. Biophys. Res. Commun. 263(1):213-218(1999)

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$ 80.00
Cat# BP9380a
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