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TAB1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q15750
Peptide ID 90625047
Additional Information
Gene ID 10454
Other Names TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TGF-beta-activated kinase 1-binding protein 1, TAK1-binding protein 1, TAB1, MAP3K7IP1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TAB1
Synonyms MAP3K7IP1
Function May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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TAB1 was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli.


Isono, T., et al. Int. J. Oncol. 35(2):425-432(2009)Prickett, T.D., et al. J. Biol. Chem. 283(28):19245-19254(2008)Neil, J.R., et al. Cancer Res. 68(5):1462-1470(2008)Conner, S.H., et al. Biochem. J. 399(3):427-434(2006)Zhou, H., et al. Mol. Cell. Biol. 26(10):3824-3834(2006)Yamaguchi, K., et al. EMBO J. 18(1):179-187(1999)

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$ 80.00
Cat# BP9382c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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