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AQR Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O60306
Peptide ID 90819138
Additional Information
Gene ID 9716
Other Names Intron-binding protein aquarius, Intron-binding protein of 160 kDa, IBP160, AQR, KIAA0560
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AQR
Synonyms KIAA0560
Function Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.
Cellular Location Nucleus. Note=Localizes to speckle-like regions of the nucleoplasm
Research Areas
Citations (0)

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Background

AQR is intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. This protein plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. This protein may act by helping the folding of the snoRNA sequence. AQR binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.

References

Hirose, T., et al. Mol. Cell 23(5):673-684(2006)Jurica, M.S., et al. RNA 8(4):426-439(2002)Sam, M., et al. Dev. Dyn. 212(2):304-317(1998)

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$ 80.00
Cat# BP9390c
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