|Other Names||Tetraspanin-33, Tspan-33, Penumbra, hPen, Proerythroblast new membrane, TSPAN33, PEN|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Predominantly expressed in erythroblasts.|
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Provided below are standard protocols that you may find useful for product applications.
TSPAN33 plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroid progenitors.
Heikens, M.J., et al. Blood 109(8):3244-3252(2007)Huang, S., et al. Genomics 86(6):674-684(2005)Chen, Z., et al. Cancer Genet. Cytogenet. 162(2):95-98(2005)
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