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CCNB1IP1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NPC3
Peptide ID 35317
Additional Information
Gene ID 57820
Other Names E3 ubiquitin-protein ligase CCNB1IP1, 632-, Cyclin-B1-interacting protein 1, Human enhancer of invasion 10, CCNB1IP1, C14orf18, HEI10
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCNB1IP1
Synonyms C14orf18, HEI10
Function Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL- gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
Cellular Location Nucleus. Chromosome. Note=Associates to the synaptonemal complex
Tissue Location Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.
Research Areas
Citations (0)

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Background

HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.

References

Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Gronholm, M., et al. Oncogene 25(32):4389-4398(2006)Toby, G.G., et al. Mol. Cell. Biol. 23(6):2109-2122(2003)

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$ 80.00
Cat# BP9400b
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