|Other Names||E3 ubiquitin-protein ligase CCNB1IP1, 632-, Cyclin-B1-interacting protein 1, Human enhancer of invasion 10, CCNB1IP1, C14orf18, HEI10|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL- gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.|
|Cellular Location||Nucleus. Chromosome. Note=Associates to the synaptonemal complex|
|Tissue Location||Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.|
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HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Gronholm, M., et al. Oncogene 25(32):4389-4398(2006)Toby, G.G., et al. Mol. Cell. Biol. 23(6):2109-2122(2003)
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