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p19 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P55273
Additional Information
Gene ID 1032
Other Names Cyclin-dependent kinase 4 inhibitor D, p19-INK4d, CDKN2D
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDKN2D
Function Interacts strongly with CDK4 and CDK6 and inhibits them.
Cellular Location Nucleus. Cytoplasm
Research Areas
Citations (0)
citation

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Background

p19 is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis.

References

Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)Zhang, W., et al. Acta Biochim. Biophys. Sin. (Shanghai) 41(5):414-428(2009)Agarwal, S.K., et al. J. Clin. Endocrinol. Metab. 94(5):1826-1834(2009)Goode, E.L., et al. Cancer Epidemiol. Biomarkers Prev. 18(3):935-944(2009)Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18(1):255-259(2009)

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$ 277.78
Cat# BP9406a
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