|Other Names||Protein diaphanous homolog 2, Diaphanous-related formin-2, DRF2, DIAPH2, DIA|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton.|
|Cellular Location||Isoform 3: Cytoplasm, cytosol. Early endosome. Note=Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes|
|Tissue Location||Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes|
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DIAPH2 belongs to the diaphanous subfamily of the formin homology family of proteins. This gene may play a role in the development and normal function of the ovaries. Defects in this protein have been linked to premature ovarian failure 2.
Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Yasuda, S., et al. Nature 428(6984):767-771(2004)Gasman, S., et al. Nat. Cell Biol. 5(3):195-204(2003)Satoh, S., et al. J. Biol. Chem. 276(42):39290-39294(2001)
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