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DIAPH2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O60879 |
|---|
| Gene ID | 1730 |
|---|---|
| Other Names | Protein diaphanous homolog 2, Diaphanous-related formin-2, DRF2, DIAPH2, DIA |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DIAPH2 |
|---|---|
| Synonyms | DIA |
| Function | Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. |
| Cellular Location | [Isoform 3]: Cytoplasm, cytosol. Early endosome. Note=Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes |
| Tissue Location | Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
DIAPH2 belongs to the diaphanous subfamily of the formin homology family of proteins. This gene may play a role in the development and normal function of the ovaries. Defects in this protein have been linked to premature ovarian failure 2.
References
Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Yasuda, S., et al. Nature 428(6984):767-771(2004)Gasman, S., et al. Nat. Cell Biol. 5(3):195-204(2003)Satoh, S., et al. J. Biol. Chem. 276(42):39290-39294(2001)
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