|Other Names||Low molecular weight phosphotyrosine protein phosphatase, LMW-PTP, LMW-PTPase, Adipocyte acid phosphatase, Low molecular weight cytosolic acid phosphatase, Red cell acid phosphatase 1, ACP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.|
|Tissue Location||T-lymphocytes express only isoform 2.|
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Provided below are standard protocols that you may find useful for product applications.
ACP1 belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios.
Saccucci, P., et al. Med. Sci. Monit. 15 (10), CR511-CR517 (2009) :Shu, Y.H., et al. J. Clin. Endocrinol. Metab. 94(10):4094-4102(2009)Apelt, N., et al. Metab. Clin. Exp. 58(10):1415-1423(2009)Banci, M., et al. Cardiology 113(4):236-242(2009)Rousseff, R.T., et al. Neuropediatrics 39(6):354-356(2008)
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