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LRC17 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8N6Y2
Peptide ID 91109078
Additional Information
Other Names Leucine-rich repeat-containing protein 17, p37NB, LRRC17, P37NB
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LRRC17
Synonyms P37NB
Function Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity).
Cellular Location Secreted, extracellular space.
Tissue Location Expressed in osteoblast cell lines. Well expressed in ovary, heart, pancreas, skeletal muscle, lung, and fetal kidney and lung and only at the basal levels in the other tissues examined including adult kidney. More expressed in S-type neuroblastoma cells than in N-type neuroblastoma cells EMBL; U32907; AAB41565.1; -; mRNA EMBL; AY358889; AAQ89248.1; -; mRNA EMBL; AC073127; AAS07483.1; -; Genomic_DNA EMBL; BC027903; AAH27903.1; -; mRNA CCDS; CCDS34721.1; -. [Q8N6Y2-1] CCDS; CCDS5727.1; -. [Q8N6Y2-2] PIR; G02020; G02020 RefSeq; NP_001026862.1; NM_001031692.2. [Q8N6Y2-1] RefSeq; NP_005815.2; NM_005824.2. [Q8N6Y2-2] RefSeq; XP_005250165.1; XM_005250108.1. [Q8N6Y2-1] UniGene; Hs.567412; - ProteinModelPortal; Q8N6Y2; - STRING; 9606.ENSP00000344242; - iPTMnet; Q8N6Y2; - PhosphoSitePlus; Q8N6Y2; - BioMuta; LRRC17; - DMDM; 51701682; - MaxQB; Q8N6Y2; - PaxDb; Q8N6Y2; - PeptideAtlas; Q8N6Y2; - PRIDE; Q8N6Y2; - ProteomicsDB; 72249; - ProteomicsDB; 72250; -. [Q8N6Y2-2] DNASU; 10234; - Ensembl; ENST00000249377; ENSP00000249377; ENSG00000128606. [Q8N6Y2-2] Ensembl; ENST00000339431; ENSP00000344242; ENSG00000128606. [Q8N6Y2-1] GeneID; 10234; - KEGG; hsa:10234; - UCSC; uc003vat.4; human. [Q8N6Y2-1] CTD; 10234; - DisGeNET; 10234; - EuPathDB; HostDB:ENSG00000128606.12; - GeneCards; LRRC17; - HGNC; HGNC:16895; LRRC17 HPA; HPA030139; - neXtProt; NX_Q8N6Y2; - OpenTargets; ENSG00000128606; - PharmGKB; PA134866295; - eggNOG; KOG0619; Eukaryota eggNOG; COG4886; LUCA GeneTree; ENSGT00390000003913; - HOGENOM; HOG000113365; - HOVERGEN; HBG052344; - InParanoid; Q8N6Y2; - OMA; MLQIPRN; - OrthoDB; EOG091G06KH; - PhylomeDB; Q8N6Y2; - GeneWiki; LRRC17; - GenomeRNAi; 10234; - PRO; PR:Q8N6Y2; - Proteomes; UP000005640; Chromosome 7 Bgee; ENSG00000128606; - CleanEx; HS_LRRC17; - ExpressionAtlas; Q8N6Y2; baseline and differential Genevisible; Q8N6Y2; HS GO; GO:0005615; C:extracellular space; ISS:UniProtKB GO; GO:0048539; P:bone marrow development; ISS:UniProtKB GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISS:UniProtKB GO; GO:0001503; P:ossification; IEA:UniProtKB-KW Gene3D; 3.80.10.10; -; 2 InterPro; IPR000483; Cys-rich_flank_reg_C InterPro; IPR001611; Leu-rich_rpt InterPro; IPR003591; Leu-rich_rpt_typical-subtyp InterPro; IPR032675; LRR_dom_sf Pfam; PF13855; LRR_8; 2 SMART; SM00369; LRR_TYP; 6 SMART; SM00082; LRRCT; 2 PROSITE; PS51450; LRR; 6 2: Evidence at transcript level; Alternative splicing; Complete proteome; Leucine-rich repeat; Osteogenesis; Polymorphism; Reference proteome; Repeat; Secreted; Signal SIGNAL 1 18 CHAIN 19 441 Leucine-rich repeat-containing protein 17 /FTId=PRO_0000021608 REPEAT 82 103 LRR 1 REPEAT 106 127 LRR 2 REPEAT 130 151 LRR 3 DOMAIN 163 214 LRRCT 1 DOMAIN 225 268 LRRNT REPEAT 269 290 LRR 4 REPEAT 293 314 LRR 5 REPEAT 317 340 LRR 6 DOMAIN 350 402 LRRCT 2 VAR_SEQ 310 313 AAFL -> GSLR (in isoform 2) /FTId=VSP_011424 VAR_SEQ 314 441 Missing (in isoform 2) /FTId=VSP_011425 VARIANT 95 95 T -> I (in dbSNP:rs34613342) /FTId=VAR_051103 VARIANT 119 119 K -> E (in dbSNP:rs3800939) /FTId=VAR_051104 VARIANT 187 187 G -> A (in dbSNP:rs1057066) /FTId=VAR_051105 CONFLICT 214 214 Missing (in Ref. 2; AAQ89248) SEQUENCE 441 AA; 51800 MW; F629666C807A4254 CRC64; MRVVTIVILL CFCKAAELRK ASPGSVRSRV NHGRAGGGRR GSNPVKRYAP GLPCDVYTYL HEKYLDCQER KLVYVLPGWP QDLLHMLLAR NKIRTLKNNM FSKFKKLKSL DLQQNEISKI ESEAFFGLNK LTTLLLQHNQ IKVLTEEVFI YTPLLSYLRL YDNPWHCTCE IETLISMLQI PRNRNLGNYA KCESPQEQKN KKLRQIKSEQ LCNEEEKEQL DPKPQVSGRP PVIKPEVDST FCHNYVFPIQ TLDCKRKELK KVPNNIPPDI VKLDLSYNKI NQLRPKEFED VHELKKLNLS SNGIEFIDPA AFLGLTHLEE LDLSNNSLQN FDYGVLEDLY FLKLLWLRDN PWRCDYNIHY LYYWLKHHYN VHFNGLECKT PEEYKGWSVG KYIRSYYEEC PKDKLPAYPE SFDQDTEDDE WEKKHRDHTA KKQSVIITIV G
Research Areas
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Background

LRC17 involved in bone homeostasis. This protein acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors

References

Kim, T., et al. J. Biol. Chem. 284(22):15308-15316(2009)Kim, D., et al. Biochim. Biophys. Acta 1309(3):183-188(1996)

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$ 80.00
Cat# BP9419b
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