|Other Names||Anterior gradient protein 3 homolog, AG-3, AG3, hAG-3, Breast cancer membrane protein 11, AGR3, BCMP11|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.|
|Cellular Location||Endoplasmic reticulum Note=Found in the cytoplasm, which could include the endoplasmic reticulum.|
|Tissue Location||Expressed in the lung, in the ciliated cells of the airway epithelium (PubMed:25751668). Expression increased with differentiation of airway epithelial cells (PubMed:25751668) Not detected in the mucous cells (PubMed:25751668). Expressed in ciliated cells in the oviduct (PubMed:26170690). Also detected in stomach, colon, prostate and liver (PubMed:25751668). Expressed in breast, ovary, prostate and liver cancer (PubMed:26170690) Expression is associated with the level of differentiation of breast cancer (at protein level) (PubMed:26170690)|
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AGR3 (Anterior Gradient 3) protein, also known as AG3 (hAG3, HAG3 in human), or BCMP11, is a secreted cytoplasmic protein which is involved in metastasis induction and p53 tumour supressor inhibition. It may serve as molecular marker and potential therapeutic target for hormone-responsive breast tumours. Its Xenopus homolog is associated with anteroposterior fate determination during early development.
Persson, S., et al. Mol. Phylogenet. Evol. 36(3):734-740(2005)Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Fletcher, G.C., et al. Br. J. Cancer 88(4):579-585(2003)Adam, P.J., et al. J. Biol. Chem. 278(8):6482-6489(2003)
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