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CP135 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q66GS9
Additional Information
Gene ID 9662
Other Names Centrosomal protein of 135 kDa, Cep135, Centrosomal protein 4, CEP135, CEP4, KIAA0635
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CEP135 (HGNC:29086)
Synonyms CEP4, KIAA0635
Function Centrosomal microtubule-binding protein involved in centriole biogenesis (PubMed:27477386). Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole- centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865).
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles
Research Areas
Citations (0)
citation

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Background

CP135 involved in centriole biogenesis. This protein acts as a scaffolding protein during early centriole biogenesis. Also CP135 required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole.

References

Kim, K., et al. Exp. Cell Res. 314(20):3692-3700(2008)Kleylein-Sohn, J., et al. Dev. Cell 13(2):190-202(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Olsen, J.V., et al. Cell 127(3):635-648(2006)

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$ 277.78
Cat# BP9425c
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Availability: 2 weeks
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