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TCP11 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8WWU5
Peptide ID 91109287
Additional Information
Gene ID 6954
Other Names T-complex protein 11 homolog, TCP11
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TCP11
Function Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway.
Cellular Location Membrane; Single-pass membrane protein. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q01755}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q01755}. Note=Localizes on the acrosomal cap region of acrosome-intact, but not acrosome- reacted sperm. Colocalizes with MROH2B and PRKACA on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm {ECO:0000250|UniProtKB:Q01755}
Tissue Location Isoform 2 and isoform 3 are expressed in sperm. Isoform 1 is not detected in sperm (at protein level) (PubMed:21597245). Testis-specific (PubMed:11756566). Isoform 1, isoform 2 and isoform 3 are expressed in sperm (PubMed:21597245)
Research Areas
Citations (0)

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Background

TCP11 may play an important role in sperm function and fertility.

References

Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)Ma, Y.X., et al. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 25(2):122-128(2003)Ma, Y., et al. Mol. Hum. Reprod. 8(1):24-31(2002)Fraser, L.R., et al. Mol. Reprod. Dev. 48(3):375-382(1997)

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$ 80.00
Cat# BP9428a
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