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SERPINA1 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P01009
Peptide ID 80917061
Additional Information
Gene ID 5265
Other Names Alpha-1-antitrypsin, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, Short peptide from AAT, SPAAT, SERPINA1, AAT, PI
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SERPINA1
Synonyms AAT, PI
Function Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
Cellular Location Secreted. Endoplasmic reticulum. Note=The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum
Tissue Location Ubiquitous. Expressed in leukocytes and plasma.
Research Areas
Citations (0)

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Background

SERPINA1 is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease.

References

Kilty, S.J., et al. Am J Rhinol Allergy 24 (1), E4-E9 (2010) Kok, K.F., et al. BMC Gastroenterol 10, 22 (2010) Dahl, M. Clin Respir J 3(2):121-122(2009)Zhang, H., et al. Nat. Biotechnol. 21(6):660-666(2003)Mills, K., et al. Glycobiology 13(2):73-85(2003)

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$ 80.00
Cat# BP9431a
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