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LAT Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O43561
Peptide ID 42092
Additional Information
Gene ID 27040
Other Names Linker for activation of T-cells family member 1, 36 kDa phospho-tyrosine adapter protein, pp36, p36-38, LAT
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LAT
Function Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
Cellular Location Cell membrane; Single-pass type III membrane protein Note=Present in lipid rafts
Tissue Location Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).
Research Areas
Citations (0)

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LAT is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement.


Cruz-Orcutt, N., et al. Mol. Immunol. 46 (11-12), 2274-2283 (2009) Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)Shen, S., et al. J. Immunol. 182(9):5596-5604(2009)Krishnan, S., et al. J. Immunol. 181(11):8145-8152(2008)Jiang, Y., et al. Leuk. Res. 31(4):541-545(2007)

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$ 80.00
Cat# BP9432b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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