|Other Names||Neutral amino acid transporter B(0), ATB(0), Baboon M7 virus receptor, RD114/simian type D retrovirus receptor, Sodium-dependent neutral amino acid transporter type 2, Solute carrier family 1 member 5, SLC1A5, ASCT2, M7V1, RDR, RDRC|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ASCT2, M7V1, RDR, RDRC|
|Function||Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed:8702519). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
|Tissue Location||Placenta, lung, skeletal muscle, kidney, pancreas, and intestine|
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SLC1A5 (Solute carrier family 1 (neutral amino acid transporter), member 5) is a member of the Na(+)-dependent amino acid transporter superfamily. It has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids. It acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses.
# Crowther-Swanepoel, D., et al. Nat. Genet. 42(2):132-136(2010)# Wich, C., et al. Gynecol. Obstet. Invest. 68(1):9-18(2009)# Avissar, N.E., et al. Dig. Dis. Sci. 53(8):2113-2125(2008)# Broer, S. Physiol. Rev. 88(1):249-286(2008)# Deng, X., et al. BMC Psychiatry 8, 58 (2008)
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