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ELF3 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P78545
Peptide ID 80902014
Additional Information
Gene ID 1999
Other Names ETS-related transcription factor Elf-3, E74-like factor 3, Epithelial-restricted with serine box, Epithelium-restricted Ets protein ESX, Epithelium-specific Ets transcription factor 1, ESE-1, ELF3 (HGNC:3318)
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ELF3 (HGNC:3318)
Function Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).
Cellular Location Cytoplasm. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237, ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:17060315}. Note=Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism.
Tissue Location Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin.
Research Areas
Citations (0)

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Lee, S.H., et al. Mol. Cancer Ther. 7(12):3739-3750(2008)Wu, J., et al. Cell Res. 18(6):649-663(2008)Peng, H., et al. J. Cell. Physiol. 215(2):562-573(2008)Iwai, S., et al. Oral Dis 14(2):144-149(2008)Manavathi, B., et al. J. Biol. Chem. 282(27):19820-19830(2007)Choi, S.G., et al. J. Biol. Chem. 273(1):110-117(1998)

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$ 80.00
Cat# BP9441b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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