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MAGG1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96MG7
Additional Information
Gene ID 56160
Other Names Melanoma-associated antigen G1, Hepatocellular carcinoma-associated protein 4, MAGE-G1 antigen, Necdin-like protein 2, NDNL2, HCA4, MAGEG1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NSMCE3 (HGNC:7677)
Synonyms HCA4, MAGEG1, NDNL2
Function Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity).
Cellular Location Cytoplasm. Nucleus. Chromosome, telomere
Tissue Location Ubiquitous..
Research Areas
Citations (0)
citation

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Background

This intronless gene encodes a member of the MAGE superfamily. The encoded protein is 76% identical to the mouse mage-g1 protein.

References

Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1345-1354 (2008) Taylor, E.M., et al. Mol. Cell. Biol. 28(4):1197-1206(2008)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Andersen, J.S., et al. Nature 433(7021):77-83(2005)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Chibuk, T.K., et al. BMC Genet. 2, 22 (2001) :

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$ 277.78
Cat# BP9446b
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