|Other Names||Cytokine receptor common subunit gamma, Interleukin-2 receptor subunit gamma, IL-2 receptor subunit gamma, IL-2R subunit gamma, IL-2RG, gammaC, p64, CD132, IL2RG|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Common subunit for the receptors for a variety of interleukins.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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IL2RG is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.
Ross, J.A., et al. J. Biol. Chem. 285(6):3582-3591(2010)Ameratunga, R., et al. N. Z. Med. J. 122(1304):46-53(2009)Clark, P.A., et al. Hum. Genet. 96(4):427-432(1995)
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