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CTLA4 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P16410
Additional Information
Gene ID 1493
Other Names Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, CTLA4, CD152
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CTLA4
Synonyms CD152
Function Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Cellular Location Cell membrane; Single-pass type I membrane protein. Note=Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalization
Tissue Location Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.
Research Areas
Citations (0)
citation

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Background

CTLA4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer.

References

Mosbruger, T.L., et al. J. Infect. Dis. 201(9):1371-1380(2010)Zhao, S.X., et al. PLoS ONE 5 (3), E9821 (2010) Oaks, M.K., et al. Cell. Immunol. 201(2):144-153(2000)Chikuma, S., et al. J. Cell. Biochem. 78(2):241-250(2000)Magistrelli, G., et al. Eur. J. Immunol. 29(11):3596-3602(1999)

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$ 277.78
Cat# BP9453b
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