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PREX1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8TCU6
Peptide ID 90723104
Additional Information
Gene ID 57580
Other Names Phosphatidylinositol 3, 5-trisphosphate-dependent Rac exchanger 1 protein, P-Rex1, PtdIns(3, 5)-dependent Rac exchanger 1, PREX1, KIAA1415
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PREX1
Synonyms KIAA1415
Function Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Cellular Location Cytoplasm, cytosol. Cell membrane. Note=Mainly cytosolic. Some amount is apparently associated to the plasma membrane
Tissue Location Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues
Research Areas
Citations (0)

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The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.


Carretero-Ortega, J., et al. Mol. Pharmacol. 77(3):435-442(2010)Ledezma-Sanchez, B.A., et al. Biochem. Biophys. Res. Commun. 391(4):1647-1652(2010)Takefuji, M., et al. J. Hum. Genet. 55(1):42-49(2010)Qin, J., et al. Oncogene 28(16):1853-1863(2009)Waters, J.E., et al. J. Cell. Sci. 121 (PT 17), 2892-2903 (2008)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Weiner, O.D. Curr. Biol. 12 (12), R429-R431 (2002)

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$ 80.00
Cat# BP9461c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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