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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   TNFRSF1B Antibody (C-term) Blocking Peptide   

TNFRSF1B Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P20333
Peptide ID 90713215
Additional Information
Gene ID 7133
Other Names Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor 2, TNF-R2, Tumor necrosis factor receptor type II, TNF-RII, TNFR-II, p75, p80 TNF-alpha receptor, CD120b, Etanercept, Tumor necrosis factor receptor superfamily member 1b, membrane form, Tumor necrosis factor-binding protein 2, TBP-2, TBPII, TNFRSF1B, TNFBR, TNFR2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms TNFBR, TNFR2
Function Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein Tumor necrosis factor-binding protein 2: Secreted
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.


Potter, C., et al. Pharmacogenet. Genomics 20(5):338-341(2010)Dhiman, N., et al. Immunogenetics 62(4):197-210(2010)Dickinson, A.M., et al. Haematologica (2010) In press Davila, S., et al. Genes Immun. (2010) In press Cheng, X., et al. J. Alzheimers Dis. 19(2):621-630(2010)

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$ 80.00
Cat# BP9463b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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