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TNFRSF1B Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P20333
Additional Information
Gene ID 7133
Other Names Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor 2, TNF-R2, Tumor necrosis factor receptor type II, TNF-RII, TNFR-II, p75, p80 TNF-alpha receptor, CD120b, Etanercept, Tumor necrosis factor receptor superfamily member 1b, membrane form, Tumor necrosis factor-binding protein 2, TBP-2, TBPII, TNFRSF1B, TNFBR, TNFR2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNFRSF1B
Synonyms TNFBR, TNFR2
Function Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Cellular Location [Isoform 1]: Cell membrane; Single-pass type I membrane protein [Tumor necrosis factor-binding protein 2]: Secreted
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.

References

Potter, C., et al. Pharmacogenet. Genomics 20(5):338-341(2010)Dhiman, N., et al. Immunogenetics 62(4):197-210(2010)Dickinson, A.M., et al. Haematologica (2010) In press Davila, S., et al. Genes Immun. (2010) In press Cheng, X., et al. J. Alzheimers Dis. 19(2):621-630(2010)

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$ 277.78
Cat# BP9463b
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