|Other Names||BMP/retinoic acid-inducible neural-specific protein 1, Deleted in bladder cancer protein 1, BRINP1, DBC1, DBCCR1, FAM5A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DBC1, DBCCR1, FAM5A|
|Function||Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway.|
|Tissue Location||Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle, kidney, thymus, prostate, testis and small intestine.|
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Provided below are standard protocols that you may find useful for product applications.
DBC1 is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.
Koyama, S., et al. Biochem. Biophys. Res. Commun. 392(3):357-362(2010)Gronbaek, K., et al. Mod. Pathol. 21(5):632-638(2008)Louhelainen, J.P., et al. Oncogene 25(16):2409-2419(2006)Izumi, H., et al. Hum. Mol. Genet. 14(8):997-1007(2005)Beetz, C., et al. Oncol. Rep. 13(2):335-340(2005)Nishiyama, H., et al. Oncogene 20(23):2956-2964(2001)
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