IL26 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NPH9 |
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Gene ID | 55801 |
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Other Names | Interleukin-26, IL-26, Protein AK155, IL26, AK155 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | IL26 |
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Synonyms | AK155 |
Function | May play a role in local mechanisms of mucosal immunity and seems to have a pro-inflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. |
Cellular Location | Secreted. |
Tissue Location | Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T- cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
IL26 is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri.
References
??iezen, C.L., et al. Pediatr. Infect. Dis. J. 28(4):333-335(2009)??ilverberg, M.S., et al. Nat. Genet. 41(2):216-220(2009)??antarci, O.H., et al. Arch. Neurol. 65(3):349-357(2008)??or, S., et al. J. Biol. Chem. 279(32):33343-33351(2004)
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