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GNB2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P62879 |
|---|
| Gene ID | 2783 |
|---|---|
| Other Names | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2, G protein subunit beta-2, Transducin beta chain 2, GNB2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GNB2 |
|---|---|
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
| Cellular Location | Cytoplasm, perinuclear region. Cell membrane |
| Tissue Location | Expressed in all cardiac subcompartments and in the brain, with highest levels in the atrioventricular node and brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR.
References
DePuy, S.D., et al. Proc. Natl. Acad. Sci. U.S.A. 103(39):14590-14595(2006)Waragai, M., et al. J. Neurosci. Res. 83(7):1170-1178(2006)Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
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